Description
A 5-HT1A agonist (IC50 = 4.3 nM in a radioligand binding assay); selective for 5-HT1A over 5-HT2 and α1-adrenergic receptors (IC50s = 697 and 630 nM, respectively), as well as a panel of 13 additional neurotransmitter receptors and ion channels (IC50s = ≥10 µM for all) but also binds σ receptors (IC50 = 73 nM); increases NGF-induced neurite outgrowth and α-actinin levels in PC12 cells at 250 nM; decreases hippocampal neuronal damage and reduces impairments in sensorimotor function in rat models of transient global ischemia induced by 4-VO and sciatic nerve crush injury, respectively, at 10 mg/kg per day; inhibits CNS mononuclear cell infiltration and increases in cerebrospinal fluid IgG levels in a rat model of EAE induced by myelin basic protein at 10 mg/kg per day
Formal name: 1,2,3,6-tetrahydro-1-[2-(2-naphthalenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-pyridine, monohydrochloride
Synonyms: SR 57746A
Molecular weight: 417.9
CAS: 90494-79-4
Purity: ≥98%
Formulation: A crystalline solid
