A PKC inhibitor (IC50s = 1.9 and 0.4 nM for PKCα and PKCθ

LXS-196 – 10 mg

Brand:
Cayman
CAS:
1874276-76-2
Storage:
-20
UN-No:
Non-Hazardous - /

LXS-196 is a PKC inhibitor (IC50s = 1.9 and 0.4 nM for PKCα and PKCθ, respectively).{52782} It is selective for PKCα and PKCθ over GSK3β (IC50 = 3,100 nM). It inhibits proliferation of TMD8 B cell lymphoma and 92.1 uveal melanoma cells (IC50s = 900 and 184 nM, respectively) but not SK-MEL-28 skin melanoma cells (IC50 = >10,000 nM).  

 

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SKU: 31455 - 10 mg Category:

Description

A PKC inhibitor (IC50s = 1.9 and 0.4 nM for PKCα and PKCθ, respectively); selective for PKCα and PKCθ over GSK3β (IC50 = 3,100 nM); inhibits proliferation of TMD8 B cell lymphoma and 92.1 uveal melanoma cells (IC50s = 900 and 184 nM, respectively) but not SK-MEL-28 skin melanoma cells (IC50 = >10,000 nM)

Formal name: 3-amino-N-[3-(4-amino-4-methyl-1-piperidinyl)-2-pyridinyl]-6-[3-(trifluoromethyl)-2-pyridinyl]-2-pyrazinecarboxamide

Synonyms: 

Molecular weight: 472.5

CAS: 1874276-76-2

Purity: ≥95%

Formulation: A crystalline solid

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