Description
An adenosine A2A and A2B receptor dual antagonist; inhibits the ability of adenosine to suppress activation of human CD4 or CD8 T cells, as well as monocyte-derived dendritic cells, in vitro; reduces tumor growth in an AT3-OVA syngeneic mouse model alone or in combination with doxorubicin; acts synergistically with an anti-PD-1 antibody to reduce tumor growth in a B16/F10 syngeneic mouse model
Formal name: 3-[2-amino-6-[1-[[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]methyl]-1H-1,2,3-triazol-4-yl]-4-pyrimidinyl]-2-methyl-benzonitrile
Synonyms:
Molecular weight: 426.5
CAS: 2239273-34-6
Purity: ≥98%
Formulation: A crystalline solid
