An adenosine A2A and A2B receptor dual antagonist; inhibits the ability of adenosine to suppress activation of human CD4 or CD8 T cells

AB-928 – 10 mg

Brand:
Cayman
CAS:
2239273-34-6
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

AB-928 is an adenosine A2A and A2B receptor dual antagonist.{58116} It inhibits the ability of adenosine (Item No. 21232) to suppress activation of human CD4 or CD8 T cells, as well as monocyte-derived dendritic cells, in vitro.{58117,58118} AB-928, alone or in combination with doxorubicin (Item No. 15007), reduces tumor growth in an AT3-OVA syngeneic mouse model. It also acts synergistically with an anti-PD-1 antibody to reduce tumor growth in a B16/F10 syngeneic mouse model.  

 

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SKU: 31444 - 10 mg Category:

Description

An adenosine A2A and A2B receptor dual antagonist; inhibits the ability of adenosine to suppress activation of human CD4 or CD8 T cells, as well as monocyte-derived dendritic cells, in vitro; reduces tumor growth in an AT3-OVA syngeneic mouse model alone or in combination with doxorubicin; acts synergistically with an anti-PD-1 antibody to reduce tumor growth in a B16/F10 syngeneic mouse model

Formal name: 3-[2-amino-6-[1-[[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]methyl]-1H-1,2,3-triazol-4-yl]-4-pyrimidinyl]-2-methyl-benzonitrile

Synonyms: 

Molecular weight: 426.5

CAS: 2239273-34-6

Purity: ≥98%

Formulation: A crystalline solid

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