A non-steroidal androgen receptor antagonist (IC50 = 43 nM in a cell-based assay); binds to the androgen receptor (IC50 = 37 nM in a radioligand binding assay); selective for the androgen receptor over the progesterone receptor (IC50 = >10

PF-998425 – 5 mg

Brand:
Cayman
CAS:
1076225-27-8
Storage:
-20
UN-No:
Non-Hazardous - /

PF-998425 is a non-steroidal androgen receptor antagonist (IC50 = 43 nM in a cell-based assay).{57126} It binds to the androgen receptor (IC50 = 37 nM in a radioligand binding assay) and is selective for the androgen receptor over the progesterone receptor (IC50 = >10,000 nM). Topical administration of PF-998425 (3% twice per day) increases hair growth in a mouse model of hair growth, as well as reduces ear sebum in male Syrian golden hamsters (ED50 = 0.4% twice per day).  

 

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SKU: 31442 - 5 mg Category:

Description

A non-steroidal androgen receptor antagonist (IC50 = 43 nM in a cell-based assay); binds to the androgen receptor (IC50 = 37 nM in a radioligand binding assay); selective for the androgen receptor over the progesterone receptor (IC50 = >10,000 nM); topical administration increases hair growth in a mouse model of hair growth at 3% twice per day, as well as reduces ear sebum in male Syrian golden hamsters (ED50 = 0.4% twice per day)

Formal name: 4-[(1R,2R)-2-hydroxycyclohexyl]-2-(trifluoromethyl)-benzonitrile

Synonyms: 

Molecular weight: 269.3

CAS: 1076225-27-8

Purity: ≥98%

Formulation: A solid

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