A bacterial metabolite; active against P. vulgaris

Echinosporin – 1 mg

Brand:
Cayman
CAS:
79127-35-8
Storage:
-20
UN-No:
Non-Hazardous - /

Echinosporin is a bacterial metabolite originally isolated from Streptomyces echinosporus that has antibacterial and anticancer activities.{52687,52688,52689} It is active against P. vulgaris, S. typhosa, S. sonnei, E. coli, and B. subtilis (MICs = 100, 100, 100, 200, and 400 µg/ml, respectively).{52687} Echinosporin induces cell cycle arrest at the G2/M phase and apoptosis in, as well as inhibits proliferation of, HCT-15 human colorectal cancer cells (IC50s = 1.7, 1.75, and 247 µM, respectively).{52688} It inhibits tumor growth in murine P388 leukemia and Meth 1 fibrosarcoma models when administered at doses ranging from 10 to 80 mg/kg.{52689}  

 

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SKU: 31416 - 1 mg Category:

Description

A bacterial metabolite; active against P. vulgaris, S. typhosa, S. sonnei, E. coli, and B. subtilis (MICs = 100, 100, 100, 200, and 400 µg/ml, respectively); induces cell cycle arrest at the G2/M phase and apoptosis in, as well as inhibits proliferation of, HCT-15 human colorectal cancer cells (IC50s = 1.7, 1.75, and 247 µM, respectively); inhibits tumor growth in murine P388 leukemia and Meth 1 fibrosarcoma models at 10-80 mg/kg

Formal name: (1S,4aS,5S,7aS)-1,4a,5,7a-tetrahydro-5-hydroxy-8-oxo-1,5-(epoxymethano)cyclopenta[c]pyran-3-carboxamide

Synonyms:  NSC 357683|XK-213

Molecular weight: 223.2

CAS: 79127-35-8

Purity: ≥98%

Formulation: A solid

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