A derivative of gallic acid with antioxidant

Dodecyl Gallate – 100 g

Brand:
Cayman
CAS:
1166-52-5
Storage:
-20
UN-No:
Non-Hazardous - /

Dodecyl gallate is a derivative of the antioxidant gallic acid (Item No. 11846) that has diverse biological activities, including antioxidant, antiproliferative, and antibacterial properties.{61105,61106,61107} It inhibits proliferation of a variety of cancer cells, including WEHI-231 mouse B cell lymphoma, Daudi human lymphoma, and HT-29 human colon cancer cells (IC50s = 0.8, 1.4, and 17.0 µM, respectively).{61105} It induces apoptosis of WEHI-231 cells but not L-929 mouse fibroblasts. Dodecyl gallate decreases peroxidation of ox brain phospholipid liposomes by 71 and 76% when used at concentrations of 12 and 50 µM, respectively, and scavenges trichloromethyl peroxyl radicals at 0.05% w/v.{61106} It is active against a variety of Gram-positive bacteria, including B. subtilis (MIC = 25 µg/ml), as well as M. luteus, S. aureus, and methicillin-resistant S. aureus (MRSA; MICs = 12.5 µg/ml for all), and acts by inhibiting the bacterial membrane respiratory chain.{61107}  

 

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SKU: 31401 - 100 g Category:

Description

A derivative of gallic acid with antioxidant, antiproliferative, and antibacterial activities; inhibits proliferation of WEHI-231, Daudi, and HT-29 cancer cells (IC50s = 0.8, 1.4, and 17.0 µM, respectively); decreases peroxidation of ox brain phospholipids liposomes by 71 and 76% at 12 and 50 µM, respectively; scavenges trichloromethyl peroxyl radicals at 0.05% w/v; active against a variety of Gram-positive bacteria, including B. subtilis (MIC = 25 µg/ml), as well as M. luteus, S. aureus, and methicillin-resistant S. aureus (MRSA; MICs = 12.5 µg/ml for all)

Formal name: 3,4,5-trihydroxy-benzoic acid, dodecyl ester

Synonyms:  Gallic Acid dodecyl ester|Gallic Acid lauryl ester|Lauryl Gallate|NSC 133463

Molecular weight: 338.4

CAS: 1166-52-5

Purity: ≥98%

Formulation: A crystalline solid

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