An alkaloid with anticancer properties; cytotoxic to KB

5-Methoxycanthinone – 1 mg

Brand:
Cayman
CAS:
15071-56-4
Storage:
-20
UN-No:
Non-Hazardous - /

5-Methoxycanthinone is an alkaloid that has been found in L. floridana and has anticancer properties.{60001} It is cytotoxic to KB, A549, and HCT-8 cells (EC50s = 2.9, 3.1, and 2.5 µg/ml, respectively). It is active against the P. falciparum mefloquine-resistant strain F32 and the multidrug and chloroquine-resistant strain K1 (IC50s = 10.4 and 5.1 µg/ml, respectively).{60005} However, it increases the parasite load by 68.4% in a mouse model of leishmaniasis when administered at a dose of 10 mg/kg per day.{60006}  

 

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SKU: 31342 - 1 mg Category:

Description

An alkaloid with anticancer properties; cytotoxic to KB, A549, and HCT-8 cells (EC50s = 2.9, 3.1, and 2.5 µg/ml, respectively); active against the P. falciparum strains F32 and K1 (IC50s = 10.4 and 5.1 µg/ml, respectively); increases the parasite load by 68.4% in a mouse model of leishmaniasis at 10 mg/kg per day

Formal name: 5-methoxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one

Synonyms:  5-Methoxycanthin-6-one|NSC 88929

Molecular weight: 250.3

CAS: 15071-56-4

Purity: ≥95%

Formulation: A solid

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