An active tryptophan metabolite and synthetic intermediate; increases colonic production of IL-22 and restores colonization resistance to C. albicans infection in a wild-type

Indole-3-carboxaldehyde – 10 g

Brand:
Cayman
CAS:
487-89-8
Storage:
-20
UN-No:
Non-Hazardous - /

Indole-3-carboxyaldehyde is an active metabolite of tryptophan and a synthetic intermediate.{53935,53936,53937} It is produced by lactobacilli in the gut microbiota via the indole pyruvate pathway, which is catalyzed by aromatic amino acid aminotransferase (ArAT).{53935} Indole-3-carboxyaldehyde (18 mg/kg) increases colonic production of IL-22 and restores colonization resistance to C. albicans infection in a wild-type, but not aryl hydrocarbon receptor knockout (Ahr-/-), mouse model of mucosal candidiasis. It also reduces intestinal mucosal damage in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250). Indole-3-carboxaldehyde has been used as a synthetic intermediate in the synthesis of Schiff bases and ergot alkaloids.{53936,53937}  

 

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SKU: 31328 - 10 g Category:

Description

An active tryptophan metabolite and synthetic intermediate; increases colonic production of IL-22 and restores colonization resistance to C. albicans infection in a wild-type, but not Ahr-/-, mouse model of mucosal candidiasis at 18 mg/kg; reduces intestinal mucosal damage in a mouse model of DSS-induced colitis

Formal name: 1H-indole-3-carboxaldehyde

Synonyms:  Indole-3-formaldehyde|NSC 10118|β-Indolylaldehyde

Molecular weight: 145.2

CAS: 487-89-8

Purity: ≥95%

Formulation: A crystalline solid

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