Tauroursodeoxycholic acid-d5 (TUDCA-d5) is intended for use as an internal standard for the quantification of TUDCA (Item Nos. 20277 | 9003379) by GC- or LC-MS. TUDCA is a taurine-conjugated form of the secondary bile acid ursodeoxycholic acid (Item No. 15121).{25912,32137} TUDCA is found in small quantities in human bile but at a higher concentration in the bile of black bears.{32137} It demonstrates anti-apoptotic activity in rodent models of tauopathy, Huntington’s disease, ischemic brain injury, and retinal disorders.{32138,32137}
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An internal standard for the quantification of tauroursodeoxycholic acid by GC- or LC-MS
Formal name: 2-[[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl-2,2,3,4,4-d5]amino]-ethanesulfonic acid
Synonyms: 3α,7β-dihydroxy-5β-cholanoyl Taurine-d5|Sodium Tauroursodeoxycholate-d5|TUDCA-d5
Molecular weight: 504.7
CAS: 1207294-25-4
Purity: ≥99% deuterated forms (d1-d5)
Formulation: A solid
The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.
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1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}
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The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.
Available on backorder
1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}
Available on backorder