An active metabolite of tryptophan; reduces LPS-induced expression of COX-2

5-methoxy-DL-Tryptophan – 250 mg

Brand:
Cayman
CAS:
28052-84-8
Storage:
-20
UN-No:
Non-Hazardous - /

5-methoxy-DL-Tryptophan (DL-5-MTP) is an active metabolite of tryptophan with anti-inflammatory and anticancer activities.{54528,54529} It reduces LPS-induced expression of COX-2, TNF-α, IL-1β, and IL-6 in RAW 264.7 macrophages when used at a concentration of 50 mM.{54529} DL-5-MTP (23.4 mg/kg) increases survival in a mouse model of LPS-induced endotoxemia and a mouse model of sepsis induced by cecal ligation and puncture. It also reduces tumor growth and the number of metastases in an A549 mouse xenograft model when administered at a dose of 100 mg/kg.{54528}  

 

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SKU: 31222 - 250 mg Category:

Description

An active metabolite of tryptophan; reduces LPS-induced expression of COX-2, TNF-α, IL-1β, and IL-6 in RAW 264.7 macrophages at 50 mM; increases survival in a mouse model of LPS-induced endotoxemia and a mouse model of sepsis at 23.4 mg/kg; reduces tumor growth and the number of metastases in an A549 mouse xenograft model at 100 mg/kg

Formal name: 5-methoxy-tryptophan

Synonyms:  5-Methoxytryptophan|DL-5-Methoxytryptophan|DL-5-MTP

Molecular weight: 234.3

CAS: 28052-84-8

Purity: ≥98%

Formulation: A crystalline solid

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