An inhibitor of CYP4Z1 (IC50 = 5.9 µM); selective for CYP4Z1 over CYP4A11

CAY10770 – 1 mg

Brand:
Cayman
CAS:
2428734-45-4
Storage:
-20
UN-No:
De Minimis - 1231 / 3

CAY10770 is an inhibitor of the cytochrome P450 (CYP) isoform CYP4Z1 (IC50 = 5.9 µM).{57196} It is selective for CYP4Z1 over CYP4A11, CYP4F2, CYP4F3a, CYP4F3b (IC50s = 187-282 µM) but does inhibit CYP4F8 and CYP4F12 (IC50s = 167 and 91 µM, respectively). CAY10770 (3 µM) inhibits the production of 14(15)-EET, 19-HETE, and 14(15)-DiHET by 83, 86, and 80%, respectively, in T47D breast cancer cells expressing CYP4Z1.  

 

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SKU: 31216 - 1 mg Category:

Description

An inhibitor of CYP4Z1 (IC50 = 5.9 µM); selective for CYP4Z1 over CYP4A11, CYP4F2, CYP4F3a, CYP4F3b (IC50s = 187-282 µM) but does inhibit CYP4F8 and CYP4F12 (IC50s = 167 and 91 µM, respectively); inhibits 14,15-EET, 19-HETE, and 14,15-DiHET production by 83, 86, and 80%, respectively, in T47D breast cancer cells expressing CYP4Z1 at 3 µM

Formal name: 8-(1H-benzotriazol-1-ylamino)-octanoic acid

Synonyms: 

Molecular weight: 276.3

CAS: 2428734-45-4

Purity: ≥98%

Formulation: A solution in methyl acetate

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