A terpenoid indole alkaloid; an α1-AR antagonist that reduces the phenylephrine-induced pressor response in pithed rats at 1-4 mg/kg; binds to α2A-

Ajmalicine – 25 mg

Brand:
Cayman
CAS:
483-04-5
Storage:
-20
UN-No:
Non-Hazardous - /

Ajmalicine is an terpenoid indole alkaloid that has been found in R. serpentina.{21130,46769} It is an α1-adrenergic receptor antagonist, reducing the phenylephrine-induced pressor response in pithed rats when administered at doses ranging from 1 to 4 mg/kg.{61048} It also binds to α2A-, α2B-, α2C-, and α2D-adrenergic receptors (Kis = 8.2, 14.5, 5, and 289 nM, respectively).{34495} Ajmalicine, in combination with almitrine, improves hemodynamic and metabolic parameters following transient cerebral ischemia in dogs.{61049}  

 

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Description

A terpenoid indole alkaloid; an α1-AR antagonist that reduces the phenylephrine-induced pressor response in pithed rats at 1-4 mg/kg; binds to α2A-, α2B-, α2C-, and α2D-ARs (Kis = 8.2, 14.5, 5, and 289 nM, respectively); improves hemodynamic and metabolic parameters following transient cerebral ischemia in dogs when used in combination with almitrine

Formal name: (19α)-16,17-didehydro-19-methyl-oxayohimban-16-carboxylic acid, methyl ester

Synonyms:  (–)-Ajmalicine|NSC 72133|NSC 95087|Raubasine

Molecular weight: 352.4

CAS: 483-04-5

Purity: ≥98%

Formulation: A crystalline solid

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