A histamine H1 receptor antagonist; binds selectively to histamine H1 receptors (Kd = 5 nM) over H2 and H3 receptors (Kds = 1

Cyclizine (hydrochloride) – 5 g

Brand:
Cayman
CAS:
303-25-3
Storage:
-20
UN-No:
- 2811 / 6.1

Cyclizine is a histamine H1 receptor antagonist.{52784,52785,46616} It binds selectively to histamine H1 receptors (Kd = 5 nM) over H2 and H3 receptors (Kds = 1,600 and >580 nM, respectively).{46616} Cyclizine inhibits anti-IgE-induced histamine release from isolated human lung fragments with an IC50 value of 5.42 µM but induces histamine release with a 50% release concentration (RC50) of 10.81 µM.{52786} It reduces LPS-induced nitrite accumulation and protein levels of induced nitric oxide synthase (iNOS) in RAW 264.7 cells when used at a concentration of 100 nM.{52785} Cyclizine (10 and 20 mg/kg) reduces immobility in the forced swim test in rats.{52787}  

 

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SKU: 31190 - 5 g Category:

Description

A histamine H1 receptor antagonist; binds selectively to histamine H1 receptors (Kd = 5 nM) over H2 and H3 receptors (Kds = 1,600 and >580 nM, respectively); inhibits anti-IgE-induced histamine release from isolated human lung fragments (IC50 = 5.42 µM) but also induces histamine release (RC50 = 10.81 µM); reduces LPS-induced nitrite accumulation and protein levels of iNOS in RAW 264.7 cells at 100 nM; reduces immobility in the forced swim test in rats at 10 and 20 mg/kg

Formal name: 1-(diphenylmethyl)-4-methyl-piperazine, monohydrochloride

Synonyms: 

Molecular weight: 302.8

CAS: 303-25-3

Purity: ≥98%

Formulation: A solid

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