A microbial metabolite with photoprotectant and anti-inflammatory activities; reduces UVA-induced AP-2 activation

Ectoine – 50 g

Brand:
Cayman
CAS:
96702-03-3
Storage:
-20
UN-No:
Non-Hazardous - /

Ectoine is a microbial metabolite that has been found in extremophilic bacteria and has photoprotectant and anti-inflammatory activities.{54497,54498} It is biosynthesized in bacteria that grow in extreme conditions, such as high temperatures, intensive sun irradiation, and drought, to protect macromolecules against environmental stressors. Ectoine (1 mM) reduces UVA-induced AP-2 activation, ICAM1 expression, and second messenger release in isolated human keratinocytes.{54497} In vivo, ectoine (100 mg/kg) reduces intestinal crypt damage, edema, and leukocyte infiltration in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250).{54498}  

 

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SKU: 31167 - 50 g Category:

Description

A microbial metabolite with photoprotectant and anti-inflammatory activities; reduces UVA-induced AP-2 activation, ICAM1 expression, and second messenger release in isolated human keratinocytes at 1 mM; reduces intestinal crypt damage, edema, and leukocyte infiltration in a mouse model of DSS-induced colitis at 100 mg/kg

Formal name: (4S)-3,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid

Synonyms:  Ectoin|NSC 614616|Pyrostatin B

Molecular weight: 142.2

CAS: 96702-03-3

Purity: ≥95%

Formulation: A crystalline solid

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