Description
An inhibitor of tubulin polymerization (IC50 = 0.38 μM) with anticancer activit; inhibits the proliferation of HeLa, Jurkat, SNU-16, MDA-MB-231, A549, SH-SY5Y, HCT15, and KB-3-1 cells (IC50s = 83-381.2 nM) and P-glycoprotein-enriched KB-VI cells (IC50 = 215.7 nM); increases phosphorylation of JNK and Bcl-2 and induces apoptosis and cell cycle arrest at the G2/M phase in HeLa cells at 10 μM; reduces tumor growth in an HCT15 colon adenocarcinoma mouse xenograft model at 20 mg/kg
Formal name: 4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid (2E)-2-[(4-methylphenyl)methylene]hydrazide
Synonyms: SML1493
Molecular weight: 282.3
CAS: 1477482-50-0
Purity: ≥98%
Formulation: A solid
