A polyphenolic glycoside flavone with diverse biological activities; scavenges DPPH radicals (IC50 = 6.44 μg/ml); active against S. aureus

Afzelin – 1 mg

Brand:
Cayman
CAS:
482-39-3
Storage:
-20
UN-No:
Non-Hazardous - /

Afzelin is a polyphenolic glycoside flavone that has been found in B. pinnatum and has diverse biological activities.{21664,57170,57171} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals with an IC50 value of 6.44 μg/ml.{21664} Afzelin is active against S. aureus, P. aeruginosa, S. typhi, C. albicans, C. parapsilosis, and C. neoformans (MICs = 8, 16, 2, 16, 4, and 4 μg/ml, respectively). It inhibits the proliferation of A549, SKOV3, and SK-MEL-2 cells (EC50s = 40.6, 34.5, and 33.9 μg/ml, respectively).{57170} Afzelin (26 mg/kg per day) reduces the number of eosinophils, other inflammatory cells, and total cells, as well as the levels of IL-4, IL-5, and IL-13, in bronchoalveolar lavage fluid (BALF) in a mouse model of allergic asthma.{57171}  

 

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SKU: 31135 - 1 mg Category:

Description

A polyphenolic glycoside flavone with diverse biological activities; scavenges DPPH radicals (IC50 = 6.44 μg/ml); active against S. aureus, P. aeruginosa, S. typhi, C. albicans, C. parapsilosis, and C. neoformans (MICs = 8, 16, 2, 16, 4, and 4 μg/ml, respectively); inhibits the proliferation of A549, SKOV3, and SK-MEL-2 cells (EC50s = 40.6, 34.5, and 33.9 μg/ml, respectively); reduces the number of eosinophils, other inflammatory cells, and total cells, as well as the levels of IL-4, IL-5, and IL-13, in BALF in a mouse model of allergic asthma at 26 mg/kg per day

Formal name: 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Synonyms:  ​Kaempferin|Kaempferol-3-O-rhamnoside|Kaempferol-3-O-α-L-rhamnopyranoside

Molecular weight: 432.4

CAS: 482-39-3

Purity: ≥95%

Formulation: A solid

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