An anticholinergic agent; a nAChR antagonist (IC50s = 1.8

Adiphenine (hydrochloride) – 100 g

Brand:
Cayman
CAS:
50-42-0
Storage:
-20
UN-No:
Non-Hazardous - /

Adiphenine is an anticholinergic agent.{52813,52814,52815,52816} It is an antagonist of nicotinic acetylcholine receptors (nAChRs; IC50s = 1.8, 3.7, and 6.3 µM for the α3β4, α4β2, and α4β4 subunit-containing receptors, respectively), as well as muscarinic acetylcholine receptors (Ki = 0.44 µM).{52813,52814} Adiphenine inhibits contractions induced by acetylcholine (ACh) in isolated guinea pig ileum in a concentration-dependent manner.{52814} It prevents tonic hindlimb extension in a mouse model of seizures induced by maximal electroshock (MES) with an ED50 value of 62 mg/kg but is neurotoxic at higher doses.{52815} Adiphenine protects against organophosphate-induced lethality in mice with a 50% protective dose (PD50) value of 3.3 mg/kg.{52816} It has also been used as a local anesthetic.{52813,52815}  

 

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SKU: 31124 - 100 g Category:

Description

An anticholinergic agent; a nAChR antagonist (IC50s = 1.8, 3.7, and 6.3 µM for the α3β4, α4β2, and α4β4 subunit-containing receptors, respectively), as well as muscarinic acetylcholine receptors (Ki = 0.44 µM); inhibits ACh-induced contractions in isolated guinea pig ileum in a concentration-dependent manner; prevents tonic hindlimb extension in a mouse model of seizures induced by MES (ED50 = 62 mg/kg); protects against organophosphate-induced lethality in mice (PD50 = 3.3 mg/kg)

Formal name: α-phenyl-benzeneacetic acid, 2-(diethylamino)ethyl ester, monohydrochloride

Synonyms:  NSC 129224|Spasmolytin|Trasentin

Molecular weight: 347.9

CAS: 50-42-0

Purity: ≥98%

Formulation: A crystalline solid

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