A positive allosteric modulator of GLP-1R (EC50 = 0.66 µM in a reporter assay); selective for GLP-1R over GLP-2R

BETP – 5 mg

Brand:
Cayman
CAS:
1371569-69-5
Storage:
-20
UN-No:
Non-Hazardous - /

BETP is a positive allosteric modulator of glucagon-like peptide 1 receptor (GLP-1R; EC50 = 0.66 µM in a reporter assay).{58027} It is selective for GLP-1R over GLP-2R, as well as glucose-dependent insulinotropic polypeptide, glucagon, and the parathyroid hormone receptors. BETP induces cAMP accumulation and intracellular calcium mobilization in CHO cells expressing human GLP-1R (EC50s = 5 and 6.3 µM, respectively).{58028} It increases glucose-induced insulin secretion in pancreatic islets isolated from patients with type 2 diabetes when used at concentrations of 3 and 10 µM. BETP (10 mg/kg) increases plasma insulin levels in an intravenous glucose tolerance test in rats.  

 

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SKU: 31116 - 5 mg Category:

Description

A positive allosteric modulator of GLP-1R (EC50 = 0.66 µM in a reporter assay); selective for GLP-1R over GLP-2R, as well as glucose-dependent insulinotropic polypeptide, glucagon, and the parathyroid hormone receptors; induces cAMP accumulation and intracellular calcium mobilization in CHO cells expressing human GLP-1R (EC50s = 5 and 6.3 µM, respectively); increases glucose-induced insulin secretion in pancreatic islets isolated from patients with type 2 diabetes at 3 and 10 µM; increases plasma insulin levels in an intravenous glucose tolerance test in rats at 10 mg/kg

Formal name: 2-(ethylsulfinyl)-4-[3-(phenylmethoxy)phenyl]-6-(trifluoromethyl)-pyrimidine

Synonyms: 

Molecular weight: 406.4

CAS: 1371569-69-5

Purity: ≥98%

Formulation: A crystalline solid

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