An MTH1 inhibitor (IC50 = 72 nM); selective for MTH1 over a panel of 456 kinases at 1 µM; induces oxidative DNA damage and apoptosis in SGC-7901 and BGC-823 cancer cells at 30 µM; induces ROS production and apoptosis in the same model; inhibits proliferation in a panel of 14 cancer cell lines expressing wild-type or various mutant forms of K-Ras or p53 (IC50s = 0.52-7.4 µM); inhibits tumor growth in an SW 480 mouse xenograft model at 25 mg/kg

(S)-Crizotinib – 25 mg

Brand:
Cayman
CAS:
1374356-45-2
Storage:
-20
UN-No:
Non-Hazardous - /

(S)-Crizotinib is an inhibitor of muT homolog 1 (MTH1; IC50 = 72 nM).{28959} It is selective for MTH1 over a panel of 456 kinases at 1 µM. (S)-Crizotinib (30 µM) induces oxidative DNA damage and apoptosis in SGC-7901 and BGC-823 human gastric cancer cells.{59217} It inhibits proliferation in a panel of 14 cancer cell lines expressing wild-type or various mutant forms of K-Ras and p53 (IC50s = 0.52-7.4 µM).{28959} (S)-Crizotinib (25 mg/kg, s.c.) reduces tumor growth in an SW480 mouse xenograft model.{28959}  

 

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SKU: 31114 - 25 mg Category:

Description

An MTH1 inhibitor (IC50 = 72 nM); selective for MTH1 over a panel of 456 kinases at 1 µM; induces oxidative DNA damage and apoptosis in SGC-7901 and BGC-823 cancer cells at 30 µM; induces ROS production and apoptosis in the same model; inhibits proliferation in a panel of 14 cancer cell lines expressing wild-type or various mutant forms of K-Ras or p53 (IC50s = 0.52-7.4 µM); inhibits tumor growth in an SW 480 mouse xenograft model at 25 mg/kg

Formal name: 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine

Synonyms: 

Molecular weight: 450.3

CAS: 1374356-45-2

Purity: ≥98%

Formulation: A solid

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