A SOD mimetic; catalyzes dismutation of the superoxide anion with a catalytic rate constant of >2 x 107 M-1s-1; reduces carrageenan-induced paw edema and inhibits increases in paw exudate levels of TNF-α

Imisopasem Manganese – 10 mg

Brand:
Cayman
CAS:
218791-21-0
Storage:
-20
UN-No:
Non-Hazardous - /

Imisopasem manganese is a nonpeptide superoxide dismutase (SOD) mimetic.{7322} It catalyzes dismutation of the superoxide anion with a catalytic rate constant of greater than 2 x 107 M-1s-1. Imisopasem manganese (1-10 mg/kg, i.v. bolus) reduces carrageenan-induced paw edema and inhibits increases in paw exudate levels of TNF-α, IL-1β, and lactate dehydrogenase (LDH) in rats. It inhibits increases in lung and ileum myeloperoxidase (MPO) levels, indicating reduced neutrophil infiltration, and increases in plasma malondialdehyde (MDA), TNF-α, and IL-1β levels in a rat model of ischemia-reperfusion injury and shock induced by splanchnic artery occlusion (SAO) when administered at doses of 0.1, 0.3, and 1 mg/kg.  

 

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SKU: 31112 - 10 mg Category:

Description

A SOD mimetic; catalyzes dismutation of the superoxide anion with a catalytic rate constant of >2 x 107 M-1s-1; reduces carrageenan-induced paw edema and inhibits increases in paw exudate levels of TNF-α, IL-1β, and LDH in rats at 1-10 mg/kg, i.v. bolus; inhibits increases in lung and ileum MPO levels, indicating reduced neutrophil infiltration, and increases in plasma MDA, TNF-α, and IL-1β levels in a rat model of ischemia-reperfusion injury and shock induced by SAO at 0.1, 0.3, and 1 mg/kg

Formal name: (PB-7-11-2344′3′)-dichloro[(4aR,13aR,17aR,21aR)-1,2,3,4,4a,5,6,12,13,13a,14,15,16,17,17a,18,19,20,21,21a-eicosahydro-11,7-nitrilo-7H-dibenzo[b,h][1,4,7,10]tetraazacycloheptadecine-κN5,κN13,κN18,κN21,κN22]-manganese

Synonyms:  M40403

Molecular weight: 483.4

CAS: 218791-21-0

Purity: ≥95%

Formulation: A crystalline solid

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