An IKKβ NBD mimetic; inhibits the protein-protein interaction between NEMO/IKKγ and IKKβ; inhibits TNF-α-induced NF-κB activation in a reporter assay from 25-150 µM; reduces LPS-induced IL-6 production in RAW 264.7 cells; improves grip strength in the mdx mouse model of Duchenne muscular dystrophy at 30 mg/kg

SR 12460 – 5 mg

Brand:
Cayman
CAS:
2055101-66-9
Storage:
-20
UN-No:
Non-Hazardous - /

SR 12460 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.{55404} It inhibits TNF-α-induced NF-κB activation in a reporter assay when used at concentrations ranging from 25 to 150 µM. It reduces LPS-induced production of IL-6 in RAW 264.7 cells. SR 12460 (30 mg/kg) improves grip strength in the mdx mouse model of Duchenne muscular dystrophy.  

 

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SKU: 31066 - 5 mg Category:

Description

An IKKβ NBD mimetic; inhibits the protein-protein interaction between NEMO/IKKγ and IKKβ; inhibits TNF-α-induced NF-κB activation in a reporter assay from 25-150 µM; reduces LPS-induced IL-6 production in RAW 264.7 cells; improves grip strength in the mdx mouse model of Duchenne muscular dystrophy at 30 mg/kg

Formal name: N-(5-chloro-2-pyridinyl)-2-[[2-(3,5-difluorophenyl)ethyl]amino]-acetamide

Synonyms: 

Molecular weight: 325.7

CAS: 2055101-66-9

Purity: ≥98%

Formulation: A crystalline solid

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