An IKKβ NBD mimetic; inhibits the protein-protein interaction between NEMO/IKKγ and IKKβ; selectively disrupts the association of NEMO/IKKγ with IKKβ over TRAF2

SR 12343 – 5 mg

Brand:
Cayman
CAS:
2055101-86-3
Storage:
-20
UN-No:
Non-Hazardous - /

SR 12343 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.{55404} It selectively disrupts the association of NEMO/IKKγ with IKKβ over TNF receptor-associated factor 2 (TRAF2), IκBα, and IKKα in co-immunoprecipitation assays using RAW 264.7 cells at concentrations ranging from 25 to 150 µM. SR 12343 inhibits TNF-α-induced NF-κB activation in a reporter assay. It reduces increased serum IL-6 levels in a mouse model of LPS-induced endotoxemia when administered at a dose of 10 mg/kg. SR 12343 (30 mg/kg) improves grip strength and reduces muscle fibrosis in the mdx mouse model of Duchenne muscular dystrophy.  

 

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SKU: 31031 - 5 mg Category:

Description

An IKKβ NBD mimetic; inhibits the protein-protein interaction between NEMO/IKKγ and IKKβ; selectively disrupts the association of NEMO/IKKγ with IKKβ over TRAF2, IκBα, and IKKα in co-immunoprecipitation assays using RAW 264.7 cells at 25-150 µM; inhibits TNF-α-induced NF-κB activation in a reporter assay; reduces increased serum IL-6 levels in a mouse model of LPS-induced endotoxemia at 10 mg/kg; improves grip strength and reduces muscle fibrosis in the mdx mouse model of Duchenne muscular dystrophy at 30 mg/kg

Formal name: N-[2-(3-bromophenyl)ethyl]-2-[(5-chloro-2-pyridinyl)amino]-acetamide

Synonyms: 

Molecular weight: 368.7

CAS: 2055101-86-3

Purity: ≥98%

Formulation: A crystalline solid

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