An alkaloid with diverse biological activities; herbicidal against duckweed (L. minor) at 10 ppm in the growth medium; inhibits 5-HT reuptake by OCT2 and dopamine reuptake by OCT3 (IC50s = 0.137 and 0.354 µM

Dehydrocorydaline (chloride) – 25 mg

Brand:
Cayman
CAS:
10605-03-5
Storage:
-20
UN-No:
Non-Hazardous - /

Dehydrocorydaline is an alkaloid that has been found in C. yanhusuo and has diverse biological activities.{54342,54343,54344,54345} It is herbicidal against duckweed (L. minor) when used at a concentration of 10 ppm in the growth medium.{54342} Dehydrocorydaline inhibits serotonin (5-HT; Item No. 14332) reuptake by organic cation transporter 2 (OCT2) and dopamine reuptake by OCT3 (IC50s = 0.137 and 0.354 µM, respectively, for human recombinant transporters), as well as reduces dopamine, 5-HT, and norepinephrine reuptake in mouse brain synaptosomes.{54343} In vivo, dehydrocorydaline (1.5 and 3 mg/kg) decreases immobility time in the forced swim test in a mouse model of depression induced by chronic unpredictable mild stress. Dehydrocorydaline (10 mg/kg) reduces acetic acid-induced writhing in mice and increases the mechanical paw withdrawal threshold in a mouse model of bone cancer pain.{54344,54345}  

 

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SKU: 30972 - 25 mg Category:

Description

An alkaloid with diverse biological activities; herbicidal against duckweed (L. minor) at 10 ppm in the growth medium; inhibits 5-HT reuptake by OCT2 and dopamine reuptake by OCT3 (IC50s = 0.137 and 0.354 µM, respectively, for human recombinant transporters), as well as reduces dopamine, 5-HT, and norepinephrine reuptake in mouse brain synaptosomes; decreases immobility time in the forced swim test in a mouse model of depression induced by chronic unpredictable mild stress at 1.5 and 3 mg/kg; reduces acetic acid-induced writhing in mice and increases the mechanical paw withdrawal threshold in a mouse model of bone cancer pain at 10 mg/kg

Formal name: 5,6-dihydro-2,3,9,10-tetramethoxy-13-methyl-dibenzo[a,g]quinolizinium, monochloride

Synonyms: 

Molecular weight: 401.9

CAS: 10605-03-5

Purity: ≥95%

Formulation: A solid

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