An ER modulator; acts as an ER antagonist in humans

Enclomiphene (citrate) – 10 mg

Brand:
Cayman
CAS:
7599-79-3
Storage:
-20
UN-No:
Non-Hazardous - /

Enclomiphene is an estrogen receptor (ER) modulator.{53931,53932,53933} It acts as an ER antagonist in humans, sheep, and rabbits and an ER agonist in rats.{53931,53932,53933} Enclomiphene (0.34 µM) inhibits binding of 17β-estradiol (E2; Item No. 10006315) in isolated rabbit uterus.{53932} It decreases E2-induced inhibition of follicle stimulating hormone (FSH) secretion in primary sheep pituitary cells in a concentration-dependent manner.{53933} Enclomiphene (0.25 and 0.5 mg/animal) inhibits spermatogenesis and decreases serum luteinizing hormone (LH) and testosterone levels in intact or castrated rats.{53934} Formulations containing enclomiphene have been used in the treatment of ovarian dysfunction.  

 

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Description

An ER modulator; acts as an ER antagonist in humans, sheep, and rabbits and an ER agonist in rats; inhibits E2 binding in isolated rabbit uterus at 0.34 µM; decreases E2-induced inhibition of FSH secretion in primary sheep pituitary cells in a concentration-dependent manner; inhibits spermatogenesis and decreases serum LH and testosterone levels in intact or castrated rats at 0.25 and 0.5 mg/animal

Formal name: 2-[4-[(1E)-2-chloro-1,2-diphenylethenyl]phenoxy]-N,N-diethyl-ethanamine, 2-hydroxy-1,2,3-propanetricarboxylate

Synonyms:  trans-Clomiphene

Molecular weight: 598.1

CAS: 7599-79-3

Purity: ≥95%

Formulation: A crystalline solid

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