An antimalarial agent; active against chloroquine-sensitive and chloroquine-resistant strains of P. falciparum (IC50s = 1.5-2.5 and 1.3-3.9 µg/L

Halofantrine (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
36167-63-2
Storage:
-20
UN-No:
Non-Hazardous - /

Halofantrine is an antimalarial agent.{52644} It is active against chloroquine-sensitive and chloroquine-resistant strains of P. falciparum (IC50s = 1.5-2.5 and 1.3-3.9 µg/L, respectively). Halofantrine reduces parasitemia in a mouse model of P. berghei infection with a 50% curative dose (CD50) value of 15 mg/kg. It also reduces parasitemia in an Aotus monkey model of P. falciparum infection (CD50 = 58.3 mg/kg). Formulations containing halofantrine have been used in the treatment of malaria.  

 

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SKU: 30962 - 5 mg Category:

Description

An antimalarial agent; active against chloroquine-sensitive and chloroquine-resistant strains of P. falciparum (IC50s = 1.5-2.5 and 1.3-3.9 µg/L, respectively); reduces parasitemia in a mouse model of P. berghei infection (CD50 = 15 mg/kg); reduces parasitemia in an Aotus monkey model of P. falciparum infection (CD50 = 58.3 mg/kg)

Formal name: 1,3-dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-9-phenanthrenemethanol, monohydrochloride

Synonyms:  (±)-Halofantrine|SKF 102886|WR 171669

Molecular weight: 536.9

CAS: 36167-63-2

Purity: ≥98%

Formulation: A crystalline solid

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