A partial agonist of muscarinic acetylcholine receptors (Kis = 5

McNA343 – 10 mg

Brand:
Cayman
CAS:
55-45-8
Storage:
-20
UN-No:
Non-Hazardous - /

McNA343 is a partial agonist of muscarinic acetylcholine receptors (Kis = 5, 1, 5, 0.2, and 7.6 µM for M1-5 receptors, respectively, in radioligand binding assays).{56099} It induces contraction of isolated human umbilical veins (EC50 = 1.23 µM), an effect that can be reversed by various M1 muscarinic receptor selective antagonists. McNA343 also inhibits forskolin-induced cAMP production in CHO cells expressing M1 or M4 receptors, as well as phosphatidylinositol hydrolysis in CHO-K1 cells expressing M3 receptors and CHO cells expressing M5 receptors. Intrathecal administration of McNA343 inhibits compulsive hindlimb neck-scratching behavior induced by 5’-guanidinonaltrindole (GNTI) in mice. It has nootropic activity, enhancing spontaneous working memory in the Y maze in wild-type mice, and it reverses learning and memory impairments induced by bulbectomy in mice in a passive avoidance test.  

 

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SKU: 30961 - 10 mg Category:

Description

A partial agonist of muscarinic acetylcholine receptors (Kis = 5, 1, 5, 0.2, and 7.6 µM for M1-5 receptors, respectively, in radioligand binding assays); induces contraction of isolated human umbilical veins (EC50 = 1.23 µM); intrathecal administration inhibits GNTI-induced compulsive hindlimb neck-scratching behavior in mice; enhances spontaneous working memory in the Y maze in wild-type mice and reverses learning and memory impairments induced by bulbectomy in mice in a passive avoidance test

Formal name: 4-[[[(3-chlorophenyl)amino]carbonyl]oxy]-N,N,N-trimethyl-2-butyn-1-aminium, monochloride

Synonyms: 

Molecular weight: 317.2

CAS: 55-45-8

Purity: ≥98%

Formulation: A solid

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