Description
A Smac mimetic and IAP inhibitor; binds to the BIR3 domains of IAP1, IAP2, and XIAP (IC50s = 15, 21, and 15 nM, respectively); disrupts the protein-protein interaction between IAP1 and caspase-9 in vitro; induces degradation of IAP1 in (EC50 = 0.1 nM) and reduces the growth of MDA-MB-231 breast cancer cells (GI50 = + T cell, spleen, thymus, bone marrow, liver, lung, and lymph node levels of HIV RNA in a humanized mouse model of antiretroviral therapy-suppressed HIV infection at 3 mg/kg
Formal name: 3,3′-[2,4-hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide
Synonyms:
Molecular weight: 1,015.30
CAS: 1258392-53-8
Purity: ≥98%
Formulation: A crystalline solid
