A carbazole alkaloid; active against S. aureus and S. pyogenes (MIC100 = 50 µg/ml for both)

Mahanimbine – 1 mg

Brand:
Cayman
CAS:
21104-28-9
Storage:
-20
UN-No:
Non-Hazardous - /

Mahanimbine is a carbazole alkaloid that has been found in M. koenigii and has diverse biological activities.{57192,57193,57194} It is active against S. aureus and S. pyogenes (MIC100 = 50 µg/ml for both), as well as A. aegypti fourth instar larvae when used at a concentration of 100 µg/ml.{57192} Mahanimbine induces cell cycle arrest at the G0/G1 phase and apoptosis in Capan-2 and SW1190 cancer cells when used at a concentration of 7 µM, as well as inhibits proliferation in Capan-2, SW1190, BxPC-3, CFPAC-1, and HPAF-II cancer cells (IC50s = 3.5, 3.5, 16, 64, and 32 µM, respectively).{57193} It decreases body weight gain without affecting food intake and reduces increases in plasma total cholesterol and triglyceride levels in a rat model of high-fat diet-induced obesity when administered orally at a dose of 30 mg/kg.{57194}  

 

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Description

A carbazole alkaloid; active against S. aureus and S. pyogenes (MIC100 = 50 µg/ml for both), as well as A. aegypti fourth instar larvae at 100 µg/ml; induces cell cycle arrest at the G0/G1 phase and apoptosis in Capan-2 and SW1190 cancer cells at 7 µM, as well as inhibits proliferation in Capan-2, SW1190, BxPC-3, CFPAC-1, and HPAF-II cancer cells (IC50s = 3.5, 3.5, 16, 64, and 32 µM, respectively); decreases body weight gain without affecting food intake and reduces increases in plasma total cholesterol and triglyceride levels in a rat model of high-fat diet-induced obesity at 30 mg/kg

Formal name: (3S)-3,11-dihydro-3,5-dimethyl-3-(4-methyl-3-penten-1-yl)-pyrano[3,2-a]carbazole

Synonyms: 

Molecular weight: 331.5

CAS: 21104-28-9

Purity: ≥98%

Formulation: A solid

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