An NLRP3 inflammasome inhibitor; selective for NLRP3 over NLRP4 and AIM2 inflammasomes at 400 µM; inhibits LPS-induced IL-1β release and ASC oligomerization in J774A.1 mouse macrophages; reduces infarct size and cardiac levels of troponin I in a mouse model of acute myocardial infarction at 100 mg/kg; reduces peritoneal leukocyte infiltration in a mouse model of zymosan A-induced peritonitis; decreases plasma IL-18 levels and reduces systolic and diastolic dysfunction in a mouse model of Western diet-induced obesity at 100 mg/kg

NLRP3i – 1 g

Brand:
Cayman
CAS:
16673-34-0
Storage:
-20
UN-No:
Non-Hazardous - /

NLRP3i is an intermediate in the synthesis of glyburide (Item No. 15009) and an inhibitor of the NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome.{54178} It is selective for NLRP3 over NLRP4 and absent in melanoma 2 (AIM2) inflammasomes at 400 µM. NLRPi inhibits LPS-induced IL-1β release and apoptosis-associated speck-like protein containing a CARD (ASC) oligomerization in J774A.1 mouse macrophages. In vivo, NLRP3i (100 mg/kg) reduces infarct size and cardiac levels of troponin I in a mouse model of acute myocardial infarction. It reduces peritoneal leukocyte infiltration in a mouse model of peritonitis induced by zymosan A (Item No. 21175) in a dose-dependent manner. NLRP3i (100 mg/kg) also decreases plasma IL-18 levels and reduces systolic and diastolic dysfunction in a mouse model of Western diet-induced obesity.{54179}  

 

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Description

An NLRP3 inflammasome inhibitor; selective for NLRP3 over NLRP4 and AIM2 inflammasomes at 400 µM; inhibits LPS-induced IL-1β release and ASC oligomerization in J774A.1 mouse macrophages; reduces infarct size and cardiac levels of troponin I in a mouse model of acute myocardial infarction at 100 mg/kg; reduces peritoneal leukocyte infiltration in a mouse model of zymosan A-induced peritonitis; decreases plasma IL-18 levels and reduces systolic and diastolic dysfunction in a mouse model of Western diet-induced obesity at 100 mg/kg

Formal name: N-[2-[4-(aminosulfonyl)phenyl]ethyl]-5-chloro-2-methoxy-benzamide

Synonyms: 

Molecular weight: 368.8

CAS: 16673-34-0

Purity: ≥95%

Formulation: A crystalline solid

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