A diterpene alkaloid with cardioprotective activity; reduces sodium pentobarbital-induced cell death in primary neonatal rat cardiomyocytes from 0.1-10 µM; reduces isoproterenol-induced production of ROS and apoptosis in H9c2 rat cardiomyocytes at 0.5 µM; reduces isoproterenol-induced myocardial necrosis and fibrosis in rats at 3 and 10 mg/kg

Fuziline – 10 mg

Brand:
Cayman
CAS:
80665-72-1
Storage:
-20
UN-No:
Excepted Quantity - 1544 / 6.1

Fuziline is a diterpene alkaloid that has been found in A. lateralis and has cardioprotective activity.{54422} It reduces sodium pentobarbital-induced cell death in primary neonatal rat cardiomyocytes when used at concentrations ranging from 0.1 to 10 µM. Fuziline (0.5 µM) reduces the production of reactive oxygen species (ROS) and apoptosis induced by isoproterenol (Item No. 15592) in H9c2 rat cardiomyocytes.{54421} In vivo, fuziline (3 and 10 mg/kg) reduces isoproterenol-induced myocardial necrosis and fibrosis in rats.  

 

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SKU: 30889 - 10 mg Category:

Description

A diterpene alkaloid with cardioprotective activity; reduces sodium pentobarbital-induced cell death in primary neonatal rat cardiomyocytes from 0.1-10 µM; reduces isoproterenol-induced production of ROS and apoptosis in H9c2 rat cardiomyocytes at 0.5 µM; reduces isoproterenol-induced myocardial necrosis and fibrosis in rats at 3 and 10 mg/kg

Formal name: (1α,6α,14α,15α,16β)-20-ethyl-6,16-dimethoxy-4-(methoxymethyl)-aconitane-1,8,14,15-tetrol

Synonyms:  Senbusine C

Molecular weight: 453.6

CAS: 80665-72-1

Purity: ≥95%

Formulation: A crystalline solid

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