A flavonoid with diverse biological activities; inhibits 5-LO and 12-LO (IC50s = 0.1 and 1 µM

Cirsiliol – 1 mg

Brand:
Cayman
CAS:
34334-69-5
Storage:
-20
UN-No:
Non-Hazardous - /

Cirsiliol is a flavonoid that has been found in S. indicum and has diverse biological activities.{54227} It inhibits 5-lipoxygenase (5-LO) and 12-LO (IC50s = 0.1 and 1 µM, respectively).{54227} Cirsiliol inhibits the release of slow-reacting substance of anaphylaxis (SRS-A) in passively sensitized isolated guinea pig lung (IC50 = 0.4 µM). It induces relaxation of precontracted isolated rat uterus, urinary bladder, proximal aorta, and trachea in a concentration-dependent manner.{54228} Cirsiliol inhibits colony formation and migration of B16/F10 murine melanoma cells.{54229} In vivo, cirsiliol (200 µg/kg) enhances radiation-induced inhibition of tumor growth in an H1299 non-small cell lung cancer (NSCLC) mouse xenograft model.{54230}  

 

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SKU: 30874 - 1 mg Category:

Description

A flavonoid with diverse biological activities; inhibits 5-LO and 12-LO (IC50s = 0.1 and 1 µM, respectively); inhibits release of SRS-A in passively sensitized isolated guinea pig lung (IC50 = 0.4 µM); induces relaxation of isolated precontracted rat uterus, urinary bladder, proximal aorta, and trachea; inhibits colony formation and migration of B16/F10 murine melanoma cells; enhances radiation-induced inhibition of tumor growth in an H1299 NSCLC mouse xenograft model at 200 µg/kg

Formal name: 2-(3,4-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxy-4H-1-benzopyran-4-one

Synonyms:  Crisiliol

Molecular weight: 330.3

CAS: 34334-69-5

Purity: ≥90%

Formulation: A crystalline solid

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