Solanesol – 10 g

Brand:
Cayman
CAS:
13190-97-1
Storage:
-20
UN-No:
Non-Hazardous - /

Solanesol is a trisesquiterpenoid that has been found in N. tabacum and has diverse biological activities.{56187,56188,56189} It is active against E. coli, M. phlei, P. aeruginosa, and S. aureus.{56187} Solanesol (40 µM) increases basal heme oxygenase-1 (HO-1) and nuclear factor erythroid 2-related factor 2 (Nrf2) activities and inhibits LPS-induced production of IL-6, IL-1β, and TNF-α in RAW 264.7 cells.{56188} It reduces escape latency in the Morris water maze and the number of slips in a beam-crossing task in a rat model of Huntington’s disease induced by 3-nitropropionic acid (3-NP; Item No. 14684) when administered at doses of 5, 10, and 15 mg/kg.{56189} Solanesol is also a precursor in the formation of polynuclear aromatic hydrocarbons (PAHs), which are carcinogenic components of tobacco smoke, and has been used as a synthetic intermediate in the synthesis of coenzyme Q10 (Item No. 11506) and vitamin K analogs that have antioxidant activities.{56187}  

 

Available on backorder

SKU: 30867 - 10 g Category:

Description

A trisesquiterpenoid; active against E. coli, M. phlei, P. aeruginosa, and S. aureus, increases basal HO-1 and Nrf2 activities and inhibits LPS-induced production of IL-6, IL-1β, and TNF-α in RAW 264.7 cells at 40 µM; reduces escape latency in the Morris water maze and the number of slips in a beam crossing task in a rat model of Huntington’s disease induced by 3-NP at 5, 10, and 15 mg/kg; a precursor in the formation of PAHs and a synthetic intermediate in the synthesis of coenzyme Q10 and vitamin K analogs that have antioxidant activities


Formal name: (2E,6E,10E,14E,18E,22E,26E,30E)-3,7,11,15,19,23,27,31,35-nonamethyl-2,6,10,14,18,22,26,30,34-hexatriacontanonaen-1-ol

Synonyms: 

Molecular weight: 631.1

CAS: 13190-97-1

Purity: ≥95%

Formulation: A solid