An oxidized sterol; active against the P. falciparum chloroquine-sensitive strain FCA 20/GHA (IC50 = 8.2 µM); induces apoptosis in LNCaP and DU145 prostate cancer cells from 6.25-50 µM; inhibits growth of SNU-1 gastric

Ergosterol Peroxide – 500 µg

Brand:
Cayman
CAS:
2061-64-5
Storage:
-20
UN-No:
Non-Hazardous - /

Ergosterol peroxide is an oxidized sterol and derivative of ergosterol (Item No. 19850) that has been found in S. aspratus and has diverse biological activities.{59102,59103,59104,59105,59106} It is active against the P. falciparum chloroquine-sensitive strain FCA 20/GHA with an IC50 value of 8.2 µM.{59103} Ergosterol peroxide (6.25-50 µM) induces apoptosis in LNCaP and DU145 prostate cancer cells.{59104} It inhibits growth of SNU-1 gastric, SNU-354 hepatoma, and SNU-C4 colorectal cancer cells (IC50s = 18.7, 158.2, and 84.6 µM, respectively).{59107} Ergosterol peroxide (60 µM) inhibits LPS-induced NF-kB DNA-binding activity and production of TNF-α in RAW 264.7 cells.{59105} Topical application of ergosterol peroxide reduces ear edema in a mouse model of inflammation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) with an ID50 value of 0.2 mg/ear.{59106}  

 

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Description

An oxidized sterol; active against the P. falciparum chloroquine-sensitive strain FCA 20/GHA (IC50 = 8.2 µM); induces apoptosis in LNCaP and DU145 prostate cancer cells from 6.25-50 µM; inhibits growth of SNU-1 gastric, SNU-354 hepatoma, and SNU-C4 colorectal cancer cells (IC50s = 18.7, 158.2, and 84.6 µM, respectively; inhibits LPS-induced NF-kB DNA-binding activity and production of TNF-α in RAW 264.7 cells at 60 µM; reduces ear edema in a mouse model of inflammation induced by TPA (ID50 = 0.2 mg/ear)

Formal name: (3β,5α,8α,22E)-5,8-epidioxy-ergosta-6,22-dien-3-ol

Synonyms:  Ergosterol Endoperoxide|NSC 31324

Molecular weight: 428.7

CAS: 2061-64-5

Purity: ≥98%

Formulation: A crystalline solid

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