Triflumuron is an insecticide and a chitin synthesis inhibitor.{59007} It reduces cuticle thickness in T. molitor pupae when administered at doses of 1 and 2 µg/insect.{59008} Topical application of triflumuron (1 µg/insect) to female M. domestica adults reduces egg hatching by greater than 95%.{59007} It induces mortality in A. aegypti, C. quinquefasciatus, and A. stephensi third instar larvae with EC50 values of 0.2, 0.3, and 0.1 ppb, respectively.{59009} Formulations containing triflumuron have been used as insecticides in agriculture.
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An insecticide; reduces cuticle thickness in T. molitor pupae at 1 and 2 µg/insect; reduces egg hatching by >95% in female M. domestica adults at 1 µg/insect; induces mortality in A. aegypti, C. quinquefasciatus, and A. stephensi third instar larvae (EC50s = 0.2, 0.3, and 0.1 ppb, respectively)
Formal name: 2-chloro-N-[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]-benzamide
Synonyms: OMS-2015
Molecular weight: 358.7
CAS: 64628-44-0
Purity: ≥98%
Formulation: A crystalline solid
The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}
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The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}
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The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.
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1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}
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