A Mat2A inhibitor (IC50 = 420 nM for SAM production in an enzyme assay); selective for Mat2A over a panel of neurotransmitter transporters

PF-9366 – 25 mg

Brand:
Cayman
CAS:
72882-78-1
Storage:
-20
UN-No:
Non-Hazardous - /

PF-9366 is an inhibitor of methionine adenosyltransferase 2A (Mat2A; IC50 = 420 nM for S-adenosyl-L-methionine (SAM) production in an enzyme assay).{54128} It is selective for Mat2A over a panel of neurotransmitter transporters, phosphodiesterases, ion channels, and G protein-coupled receptors, as well as a panel of 39 kinases at 10 µM. PF-9366 inhibits SAM production in H520 lung carcinoma cells (IC50 = 1.2 µM) and Huh7 hepatocellular carcinoma cells (IC50 = 225 nM).  

 

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SKU: 30782 - 25 mg Category:

Description

A Mat2A inhibitor (IC50 = 420 nM for SAM production in an enzyme assay); selective for Mat2A over a panel of neurotransmitter transporters, phosphodiesterases, ion channels, and G protein-coupled receptors, as well as a panel of 39 kinases at 10 µM; inhibits SAM production in H520 lung carcinoma cells (IC50 = 1.2 µM) and Huh7 hepatocellular carcinoma cells (IC50 = 225 nM)

Formal name: 7-chloro-N,N-dimethyl-5-phenyl-[1,2,4]triazolo[4,3-a]quinoline-1-ethanamine

Synonyms: 

Molecular weight: 350.8

CAS: 72882-78-1

Purity: ≥98%

Formulation: A solid

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