An inhibitor of CREB-mediated gene transcription (IC50 = 81 nM in a cell-based reporter assay); inhibits the growth of A549

666-15 – 25 mg

Brand:
Cayman
CAS:
1433286-70-4
Storage:
-20
UN-No:
Non-Hazardous - /

666-15 is an inhibitor of gene transcription mediated by cAMP-response-element-binding protein (CREB; IC50 = 81 nM in a cell-based reporter assay).{56180} It inhibits the growth of A549, MCF-7, MDA-MB-231, and MDA-MB-468 cells (GI50s = 0.47, 0.31, 0.073, and 0.046 μM, respectively). 666-15 (10 mg/kg per day, five days per week) reduces tumor growth in an MDA-MB-468 mouse xenograft model.  

 

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SKU: 30780 - 25 mg Category:

Description

An inhibitor of CREB-mediated gene transcription (IC50 = 81 nM in a cell-based reporter assay); inhibits the growth of A549, MCF-7, MDA-MB-231, and MDA-MB-468 cells (GI50s = 0.47, 0.31, 0.073, and 0.046 μM, respectively); reduces tumor growth in an MDA-MB-468 mouse xenograft model at 10 mg/kg per day, five days per week

Formal name: 3-(3-aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide, monohydrochloride

Synonyms:  Compound 3i

Molecular weight: 620.5

CAS: 1433286-70-4

Purity: ≥98%

Formulation: A solid

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