A 5-HT receptor antagonist; inhibits 5-HT-induced effects on isolated rat uterus but not guinea pig ileum; inhibits 5-HT-induced gross excitation

Cinanserin (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
54-84-2
Storage:
-20
UN-No:
Non-Hazardous - /

Cinanserin is a serotonin (5-HT) receptor antagonist.{61112,61113} It inhibits 5-HT-induced effects on isolated rat uterus but not guinea pig ileum.{61112} Cinanserin inhibits 5-HT-induced gross excitation, gastric mucosal erosion, and anaphylactoid edema in mice and rats. Cinanserin (12 and 36 mg/kg, i.p.) impairs acquisition of a running response in rats trained for food reward.{61113} It inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) 3C-like proteinase (3CLPro; IC50 = 5 µM) and reduces SARS-CoV viral RNA levels in infected BHK-Rep-1 cells (IC50s = 19-34 µM).{61114} It also inhibits viral replication of murine hepatitis virus (MHV) in CCL-9.1 murine liver epithelial cells (IC50 = 31.25 µg/ml).{32157}  

 

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SKU: 30729 - 5 mg Category:

Description

A 5-HT receptor antagonist; inhibits 5-HT-induced effects on isolated rat uterus but not guinea pig ileum; inhibits 5-HT-induced gross excitation, gastric mucosal erosion, and anaphylactoid edema in mice and rats; impairs acquisition of a running response in rats trained for food reward at 12 and 36 mg/kg; inhibits SARS-CoV 3CLPro (IC50 = 5 µM); reduces SARS-CoV viral RNA levels in infected BHK-Rep-1 cells (IC50 = 19-34 µM)

Formal name: N-[2-[[3-(dimethylamino)propyl]thio]phenyl]-3-phenyl-2-propenamide, monohydrochloride

Synonyms:  SQ 10,643

Molecular weight: 376.9

CAS: 54-84-2

Purity: ≥98%

Formulation: A solid

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