An isoquinoline alkaloid with diverse biological activities; an inhibitor of acetylcholinesterase (IC50 = 30.6 µM); an inhibitor of BACE1 (IC50s = 33.59 and 89.07 µM for FRET and immobilized enzyme reactive assays

Corynoline – 5 mg

Brand:
Cayman
CAS:
18797-79-0
Storage:
-20
UN-No:
Non-Hazardous - /

Corynoline is an isoquinoline alkaloid that has been found in C. incisa and has diverse biological activities.{52645,52646,52647,52648,52649} It is an inhibitor of acetylcholinesterase (IC50 = 30.6 µM) and β-secretase 1 (BACE1; IC50s = 33.59 and 89.07 µM for FRET and immobilized enzyme reactive assays, respectively).{52645,52646} Corynoline (1-4 µM) decreases LPS-induced NF-κB activation and further increases LPS-induced increases in Nrf2 and heme oxygenase-1 (HO-1) protein levels in human umbilical vein endothelial cells (HUVECs).{52647} It increases the survival rate in a mouse model of LPS- and heat-killed E. coli-induced sepsis when administered at doses of 10, 20, and 40 mg/kg.{52648} Corynoline selectively inhibits proliferation of B16/F10 mouse and A375 human melanoma cells (IC50s = 12.87 and 10.47 µM, respectively) over non-cancerous melanocytes (IC50 = 126.61 µM).{52649} It halts the cell cycle at the G2 phase and induces apoptosis and the production of reactive oxygen species (ROS) in a dose-dependent manner in the same cells. It also reduces tumor growth in a B16/F10 mouse melanoma model when administered at a dose of 20 mg/kg.  

 

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Description

An isoquinoline alkaloid with diverse biological activities; an inhibitor of acetylcholinesterase (IC50 = 30.6 µM); an inhibitor of BACE1 (IC50s = 33.59 and 89.07 µM for FRET and immobilized enzyme reactive assays, respectively); decreases LPS-induced NF-κB activation and reverses LPS-induced decreases in Nrf2 and HO-1 protein levels in HUVECs; increases the survival rate in a mouse model of LPS- and heat-killed E. coli-induced sepsis at 10, 20, and 40 mg/kg; selectively inhibits proliferation of B16/F10 mouse and A375 human melanoma cells (IC50s = 12.87 and 10.47 µM, respectively) over non-cancerous melanocytes (IC50 = 126.61 µM); reduces tumor growth in a B16/F10 mouse melanoma model at 20 mg/kg

Formal name: (5bR,6S,12bR)-5b,6,7,12b,13,14-hexahydro-5b,13-dimethyl-[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol

Synonyms:  (+)-Corynoline|(d)-Corynoline|13-methyl-Chelidonine|CRL

Molecular weight: 367.4

CAS: 18797-79-0

Purity: ≥95%

Formulation: A crystalline solid

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