A β-lactam antibiotic; active against B. fragilis

Mezlocillin (sodium salt) – 250 mg

Brand:
Cayman
CAS:
59798-30-0
Storage:
-20
UN-No:
Non-Hazardous - /

Mezlocillin is a β-lactam antibiotic and derivative of ampicillin (Item No. 14417).{52600,52601} It is active against B. fragilis, E. lentum, P. morbillorum, and F. nucleatum (MICs = 8, 4, 2, and 4 µg/ml, respectively).{52601} Mezlocillin (32 µg/ml) is also active against 10 strains of S. faecalis.{52600} In vivo, mezlocillin (240 mg/kg) increases survival and reduces bacteremia in a rabbit model of S. faecalis endocarditis. It completely eliminates lung P. morbillorum, E. lentum, and F. nucelatum, but not B. fragilis, in a rabbit model of pulmonary P. morbillorum, E. lentum, F. nucelatum, and B. fragilis infection when administered at a dose of 300 mg/kg.{52601} Formulations containing mezlocillin have been used in the treatment of various bacterial infections.  

 

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SKU: 30691 - 250 mg Category:

Description

A β-lactam antibiotic; active against B. fragilis, E. lentum, P. morbillorum, and F. nucleatum (MICs = 8, 4, 2, and 4 µg/ml, respectively); active against 10 strains of S. faecalis at 32 µg/ml; increases survival and reduces bacteremia in a rabbit model of S. faecalis endocarditis; completely eliminates lung P. morbillorum, E. lentum, and F. nucelatum, but not B. fragilis, in a rabbit model of pulmonary P. morbillorum, E. lentum, F. nucelatum, and B. fragilis infection at 300 mg/kg

Formal name: [2S-[2α,5α,6β(S*)]]-3,3-dimethyl-6-[[[[[[[3-(methylsulfonyl)-2-oxo-1-imidazolidinyl]carbonyl]amino]carbonyl]amino]phenylacetyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, monosodium salt

Synonyms: 

Molecular weight: 604.6

CAS: 59798-30-0

Purity: ≥95%

Formulation: A crystalline solid

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