A CXCR4 antagonist (IC50 = 0.91 nM); inhibits HIV-1-induced cytopathogenicity in MT-4 cells (EC50 = 4 nM); reduces CXCL12-induced migration of SUP-T1 leukemia and MDA-MB-231 at 100 nM; induces apoptosis in NB4 leukemia and RPMI-8226 multiple myeloma cancer cells at 8 and 40 µM; reduces pulmonary metastasis in an MDA-MB-231 mouse xenograft model; reduces the incidence of arthritis in a mouse model of collagen-induced arthritis

BKT 140 – 1 mg

Brand:
Cayman
CAS:
664334-36-5
Storage:
-20
UN-No:
Non-Hazardous - /

BKT 140 is an antagonist of chemokine (C-X-C motif) receptor 4 (CXCR4; IC50 = 0.91 nM).{54472} It inhibits HIV-1-induced cytopathogenicity in MT-4 cells with an EC50 value of 4 nM. BKT 140 (100 nM) reduces migration of SUP-T1 leukemia and MDA-MB-231 breast cancer cells induced by chemokine (C-X-C) ligand 12 (CXCL12).{54472} It induces apoptosis in NB4 leukemia and RPMI-8226 multiple myeloma cancer cells when used at concentrations 8 and 40 µM.{54473} BKT 140 reduces pulmonary metastasis in an MDA-MB-231 mouse xenograft model.{54472} It also reduces the incidence of arthritis in a mouse model of collagen-induced arthritis.{54474}  

 

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SKU: 30689 - 1 mg Category:

Description

A CXCR4 antagonist (IC50 = 0.91 nM); inhibits HIV-1-induced cytopathogenicity in MT-4 cells (EC50 = 4 nM); reduces CXCL12-induced migration of SUP-T1 leukemia and MDA-MB-231 at 100 nM; induces apoptosis in NB4 leukemia and RPMI-8226 multiple myeloma cancer cells at 8 and 40 µM; reduces pulmonary metastasis in an MDA-MB-231 mouse xenograft model; reduces the incidence of arthritis in a mouse model of collagen-induced arthritis

Formal name: N2-(4-fluorobenzoyl)-L-arginyl-L-arginyl-3-(2-naphthalenyl)-L-alanyl-L-cysteinyl-L-tyrosyl-N5-(aminocarbonyl)-L-ornithyl-L-lysyl-D-lysyl-L-prolyl-L-tyrosyl-L-arginyl-N5-(aminocarbonyl)-L-ornithyl-L-cysteinyl-L-argininamide, cyclic (4→13)-disulfide

Synonyms:  4F-benzoyl-TN14003|BL-8040|Motixafortide|TF 14016

Molecular weight: 2,159.50

CAS: 664334-36-5

Purity: ≥95%

Formulation: A crystalline solid

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