Description
An NMDA receptor antagonist; inhibits NMDA-induced currents in rat cortical neurons (Ki = 5.4 nM); inhibits N-methyl-DL-aspartate-, PTZ-, or electroshock-induced seizures, as well as audiogenic seizures in mice (ED50s = 3.5, 2.8, 1.4, and 0.96 mg/kg, respectively); reduces the number of audiogenic seizures in a rat model of ethanol-induced withdrawal seizures at 5 mg/kg; reduces amphetamine-induced hyperactivity in rats at 2.5 and 5 mg/kg
Formal name: 7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-2(1H)-quinolinone
Synonyms:
Molecular weight: 363.8
CAS: 142326-59-8
Purity: ≥98%
Formulation: A crystalline solid
