An inhibitor of protein synthesis; inhibits the activity of a variety of enzymes

Aurintricarboxylic Acid (ammonium salt) – 50 g

Brand:
Cayman
CAS:
569-58-4
Storage:
-20
UN-No:
Non-Hazardous - /

Aurintricarboxylic acid (ATA) is an inhibitor of protein synthesis that has diverse biological activities.{54334,54335,54336,54337,54338,54339,54340,54341} It inhibits the activity of a variety of enzymes, including the nucleases DNase I, RNase A, and S1, as well as the serine proteases trypsin and chymotrypsin in a concentration-dependent manner.{54335,54336} ATA inhibits replication of severe acute respiratory syndrome coronavirus (SARS-CoV; EC50 = 200 µg/ml) and human enterovirus 71 in Vero cells (EV71; EC50 = 2.9 µM), as well as reduces HIV-1- or HIV-2-induced cytopathogenicity in MT-4 cells (IC50s = 1.1 and 0.85 µg/ml, respectively).{54337,54338,54339} It inhibits apoptosis induced by sanguinarine (Item No. 16951) in K562 leukemia cells when used at a concentration of 100 µM.{54340} ATA (20 mg/kg, i.p.) decreases CNS CD4+ T cell infiltration and reduces hind limb weakness and paralysis in a mouse model of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE).{54341}  

 

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SKU: 30636 - 50 g Category:

Description

An inhibitor of protein synthesis; inhibits the activity of a variety of enzymes, including DNase I, RNase A, and S1, as well as trypsin and chymotrypsin in a concentration-dependent manner; inhibits replication of SARS-CoV (EC50 = 200 µg/ml) and EV71 in Vero cells (EC50 = 2.9 µM), as well as reduces cytopathogenicity induced by HIV-1 and HIV-2 in MT-4 cells (IC50s = 1.1 and 0.85 µg/ml, respectively); inhibits sanguinarine-induced apoptosis in K562 leukemia cells at 100 µM; decreases CNS CD4+ T cell infiltration and reduces hind limb weakness and paralysis in a mouse model of myelin oligodendrocyte glycoprotein-induced EAE at 20 mg/kg

Formal name: 3,3′-[(3-carboxy-4-oxo-2,5-cyclohexadien-1-ylidene)methylene]bis[6-hydroxy-benzoic acid, triammonium salt

Synonyms:  ATA

Molecular weight: 473.4

CAS: 569-58-4

Purity:

Formulation: A crystalline solid

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