An NMDA receptor antagonist (IC50 = 0.008 µM); selective for NMDA receptors containing NR1A/NR2A subunits over NMDA receptors containing NR1A/NR2B subunits (IC50s = 0.27 and 29.6 µM

NVP-AAM077 – 1 mg

Brand:
Cayman
CAS:
459836-30-7
Storage:
-20
UN-No:
Non-Hazardous - /

NVP-AAM077 is an NMDA receptor antagonist (IC50 = 0.008 µM).{61130} It is selective for NMDA receptors containing NR1A/NR2A subunits over NMDA receptors containing NR1A/NR2B subunits (IC50s = 0.27 and 29.6 µM, respectively, in X. laevis oocytes expressing receptors containing the respective subunits). NVP-AAM077 inhibits seizures induced by maximal electroshock (MES) in mice with an ED50 value of 23 mg/kg. It increases the activity of neuronal nitric oxide synthase (nNOS) in primary hippocampal neurons.{61131} NVP-AAM077 (10 mg/kg) inhibits proliferation of neural progenitor cells (NPCs) in the subventricular zone (SVZ) and in the subgranular zone (SGZ) of the hippocampal dentate gyrus of adult mice, an effect not seen in nNOS-/- mice. It also increases the escape latency and decreases the percentage of time spent in the target quadrant in the Morris water maze.  

 

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SKU: 30622 - 1 mg Category:

Description

An NMDA receptor antagonist (IC50 = 0.008 µM); selective for NMDA receptors containing NR1A/NR2A subunits over NMDA receptors containing NR1A/NR2B subunits (IC50s = 0.27 and 29.6 µM, respectively); inhibits MES-induced seizures in mice (ED50 = 23 mg/kg); inhibits NPC proliferation in the SVZ and SGZ at 10 mg/kg; impairs spatial memory in the Morris water maze in mice

Formal name: P-[[[(1S)-1-(4-bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]-phosphonic acid

Synonyms:  (1RS,1’S)-PEAQX|AAM 007

Molecular weight: 454.2

CAS: 459836-30-7

Purity: ≥95% (mixture of isomers and diastereomers)

Formulation: A crystalline solid

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