A saponin with neuroprotective activity; inhibits BACE activity by 54.4% at 10 μg/ml; inhibits secretion of Aβ40 and Aβ42 from COS-7 cells expressing APP695 WT or APP695 Swe at 2 μg/ml; prevents decreases in PC12 cell viability induced by Aβ (25-35) at 20 and 40 μg/L; inhibits increases in the escape latency and total swimming distance induced by Aβ (25-35) in the Morris water maze in mice at 3 and 9 mg/kg

Tenuifolin – 10 mg

Brand:
Cayman
CAS:
20183-47-5
Storage:
-20
UN-No:
Non-Hazardous - /

Tenuifolin is a saponin that has been found in P. tenuifolia and has neuroprotective activity.{56157,56158} It inhibits β-secretase (BACE) activity by 54.4% when used at a concentration of 10 μg/ml.{56158} Tenuifolin (2 μg/ml) inhibits secretion of amyloid-β (1-40) (Aβ40) and Aβ42 from COS-7 cells expressing wild-type amyloid precursor protein isoform 695 (APP695 WT) or Swedish mutant APP695 (APP695 Swe). It prevents decreases in PC12 cell viability induced by Aβ (25-35) when used at concentrations of 20 and 40 μg/L.{56157} Tenuifolin (3 and 9 mg/kg) inhibits increases in the escape latency and total swimming distance induced by Aβ (25-35) in the Morris water maze in mice.  

 

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SKU: 30617 - 10 mg Category:

Description

A saponin with neuroprotective activity; inhibits BACE activity by 54.4% at 10 μg/ml; inhibits secretion of Aβ40 and Aβ42 from COS-7 cells expressing APP695 WT or APP695 Swe at 2 μg/ml; prevents decreases in PC12 cell viability induced by Aβ (25-35) at 20 and 40 μg/L; inhibits increases in the escape latency and total swimming distance induced by Aβ (25-35) in the Morris water maze in mice at 3 and 9 mg/kg

Formal name: (4α)-3β-(β-D-glucopyranosyloxy)-2β,27-dihydroxy-olean-12-ene-23,28-dioic acid

Synonyms:  Presenegenin 3-O-glucoside

Molecular weight: 680.8

CAS: 20183-47-5

Purity: ≥95%

Formulation: A crystalline solid

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