A β-L-nucleoside analog of thymidine that has antiviral activity; active against HBV in in HepG2/2.15 cells (EC50 = 0.1 µM); reduces virion DNA in the culture supernatant of primary hepatocytes isolated from a duckling model of chronic HBV infection from 0.01-10 µM; reduces serum viral load in a woodchuck model of chronic HBV infection at 3 and 10 mg/kg

Clevudine – 500 mg

Brand:
Cayman
CAS:
163252-36-6
Storage:
-20
UN-No:
Non-Hazardous - /

Clevudine is a β-L-nucleoside analog of thymidine (Item No. 20519) that has antiviral activity.{53860,53861,53862} It is active against hepatitis B virus (HBV) in HepG2/2.15 cells with an EC50 value of 0.1 µM.{53862} Clevudine (0.01-10 µM) reduces virion DNA in the culture supernatant of primary hepatocytes isolated from a duckling model of chronic HBV infection.{53863} Oral administration of clevudine (3 and 10 mg/kg) reduces serum viral load in a woodchuck model of chronic HBV infection.{53864}  

 

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SKU: 30612 - 500 mg Category:

Description

A β-L-nucleoside analog of thymidine that has antiviral activity; active against HBV in in HepG2/2.15 cells (EC50 = 0.1 µM); reduces virion DNA in the culture supernatant of primary hepatocytes isolated from a duckling model of chronic HBV infection from 0.01-10 µM; reduces serum viral load in a woodchuck model of chronic HBV infection at 3 and 10 mg/kg

Formal name: 1-(2-deoxy-2-fluoro-β-L-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione

Synonyms:  Levovir|L-FMAU

Molecular weight: 260.2

CAS: 163252-36-6

Purity: ≥98%

Formulation: A crystalline solid

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