An inhibitor of the RAD51-BRCA2 protein-protein interaction (EC50 = 19 µM in a cell-free competitive ELISA); decreases homologous recombination by 54% in BxPC-3 pancreatic cancer cells at 20 µM; decreases proliferation of BxPC-3 and Capan-1 cancer cells when used alone or in combination with olaparib

CAY10760 – 25 mg

Brand:
Cayman
CAS:
391889-85-3
Storage:
-20
UN-No:
Non-Hazardous - /

CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC50 = 19 µM in a cell-free competitive ELISA).{46810} It decreases homologous recombination by 54% in wild-type BRCA2-expressing BxPC-3 pancreatic cancer cells when used at a concentration of 20 µM. CAY10760 (20 µM) decreases proliferation of BxPC-3, as well as mutant BRCA2-expressing Capan-1, cancer cells when used alone or in combination with the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib (Item No. 10621).  

 

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SKU: 30532 - 25 mg Category:

Description

An inhibitor of the RAD51-BRCA2 protein-protein interaction (EC50 = 19 µM in a cell-free competitive ELISA); decreases homologous recombination by 54% in BxPC-3 pancreatic cancer cells at 20 µM; decreases proliferation of BxPC-3 and Capan-1 cancer cells when used alone or in combination with olaparib

Formal name: 6-chloro-3-[4,5-dihydro-5-(4-methoxyphenyl)-1-(1-oxopropyl)-1H-pyrazol-3-yl]-4-phenyl-2(1H)-quinolinone

Synonyms: 

Molecular weight: 486

CAS: 391889-85-3

Purity: ≥98%

Formulation: A crystalline solid

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