An inhibitor of KAT6A (IC50 = 6.3 nM); binds to KAT6A (Kd = 2 nM); selective for KAT6A over KAT5 and KAT7 (Kds = 2

WM-1119 – 50 mg

Brand:
Cayman
CAS:
2055397-28-7
Storage:
-20
UN-No:
Non-Hazardous - /

WM-1119 is an orally bioavailable inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ; IC50 = 6.3 nM).{54159} It binds to KAT6A with a Kd value of 2 nM and is selective for KAT6A over KAT5 and KAT7 (Kds = 2,200 and 500 nM, respectively), as well as over a panel of 159 additional targets at 1 and 10 μM.{51034} WM-1119 inhibits proliferation of EMRK1184 B cell lymphoma cells (IC50 = 0.25 μM). It reduces tumor growth and spleen weight in a murine EMRK1184 model when administered at a dose of 50 mg/kg four times per day.  

 

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SKU: 30509 - 50 mg Category:

Description

An inhibitor of KAT6A (IC50 = 6.3 nM); binds to KAT6A (Kd = 2 nM); selective for KAT6A over KAT5 and KAT7 (Kds = 2,200 and 500 nM, respectively), as well as a panel of 159 additional targets at 1 and 10 μM; inhibits proliferation of EMRK1184 B cell lymphoma cells (IC50 = 0.25 μM); reduces tumor growth and spleen weight in a murine EMRK1184 model at 50 mg/kg four times per day

Formal name: 3-fluoro-5-(2-pyridinyl)-benzoic acid, 2-[(2-fluorophenyl)sulfonyl]hydrazide

Synonyms: 

Molecular weight: 389.4

CAS: 2055397-28-7

Purity: ≥98%

Formulation: A crystalline solid

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