A nucleoside analog and PNP inhibitor (IC50s = 1.19

Forodesine – 5 mg

Brand:
Cayman
CAS:
209799-67-7
Storage:
-20
UN-No:
Non-Hazardous - /

Forodesine is a purine nucleoside analog and purine nucleoside phosphorylase (PNP) inhibitor (IC50s = 1.19, 0.48, 1.24, 0.66, and 1.57 nM for human, mouse, rat, monkey, and dog PNP, respectively).{55073} It inhibits phytohemagglutinin A-, mixed lymphocyte reaction-, or IL-2-induced proliferation of isolated human peripheral blood lymphocytes (PBLs; IC50s = In vivo, forodesine (10 mg/kg) prolongs survival in the hu-PBL-SCID mouse model of xenogeneic graft versus host disease (GVHD).{55073}  

 

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SKU: 30475 - 5 mg Category:

Description

A nucleoside analog and PNP inhibitor (IC50s = 1.19, 0.48, 1.24, 0.66, and 1.57 nM for human, mouse, rat, monkey, and dog PNP, respectively); inhibits phytohemagglutinin A-, mixed lymphocyte reaction-, or IL-2-induced proliferation of isolated human PBLs in the presence of dGuo; inhibits proliferation of CEM-SS T-ALL; prolongs survival in the hu-PBL-SCID mouse model of xenogeneic GVHD

Formal name: 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

Synonyms:  BCX-1777|Immucillin H

Molecular weight: 266.3

CAS: 209799-67-7

Purity: ≥95%

Formulation: A crystalline solid

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