Description
An antiviral nucleoside analog; metabolized to an active triphosphate form that induces RNA chain termination and inhibits viral polymerases; active against MERS-CoV and SARS-CoV in infected primary HAE cells (EC50s = 0.86 and 0.18 µM, respectively); reduces viral plaque formation in SARS-CoV-2-infected Vero E6 and Calu-3 2B4 cells (EC50s = 0.42 and 0.62 mM, respectively); cytoprotective against HCV, YFV, DENV-2, influenza A, and parainfluenza 3 in cell-based assays (EC50s = 4.1, 11, 9.46, 27.9, and 1.71 µM, respectively)
Formal name: 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile
Synonyms:
Molecular weight: 291.3
CAS: 1191237-69-0
Purity: ≥98%
Formulation: A solid
